研究業績

黒滝は2024年10月よりJST創発的研究支援事業「クロマチン高次構造の生体内機能を理解する」に採択されています。

  1. Saeki K, Pan R, Lee E, Kurotaki D, Ozato K: IRF8 defines the epigenetic landscape in postnatal microglia, thereby directing their transcriptome programs. Nat Immunol 25(10):1928-1942, 2024.
    https://www.nature.com/articles/s41590-024-01962-2

  2. Komohara Y, Kurotaki D# (#co-first author), Tsukamoto H, Miyasato Y, Yano H, Pan C, Yamamoto Y, Fujiwara Y: Involvement of protumor macrophages in breast cancer progression and characterization of macrophage phenotypes. Cancer Sci 114(6):2220-2229, 2023.
    https://onlinelibrary.wiley.com/doi/full/10.1111/cas.15751

  3. Kurotaki D* (*corresponding author), Kikuchi K# (#co-first author), Cui K, Kawase W, Saeki K, Fukumoto J, Nishiyama A, Nagamune K, Zhao K, Ozato K, Rocha PP, Tamura T: Chromatin structure undergoes global and local reorganization during murine dendritic cell development and activation. Proc Natl Acad Sci USA 119(34): e2207009119, 2022.
    https://doi.org/10.1073/pnas.2207009119

  4. Kawase W, Kurotaki D* (*corresponding author), Suzuki Y, Ishihara H, Ban T, Sato GR, Ichikawa J, Yanai H, Taniguchi T, Tsukahara K, Tamura T: Irf5 siRNA-loaded biodegradable lipid nanoparticles ameliorate concanavalin A-induced liver injury. Mol Ther Nucleic Acids 25: 708-715, 2021.
    https://www.sciencedirect.com/science/article/pii/S2162253121002171

  5. Kurotaki D* (*corresponding author), Yoshida H, Tamura T: Epigenetic and transcriptional regulation of osteoclast differentiation: Bone 138: 115471, 2020. Review
    https://www.sciencedirect.com/science/article/pii/S8756328220302519

  6. Kurotaki D* (*corresponding author), Kawase W, Sasaki H, Nakabayashi J, Nishiyama A, Morse HC 3rd, Ozato K, Suzuki Y, Tamura T: Epigenetic control of early dendritic cell lineage specification by the transcription factor IRF8 in mice: Blood 133(17): 1803-1813, 2019. Selected as a Plenary Paper 
    https://ashpublications.org/blood/article/133/17/1803/275917/Epigenetic-control-of-early-dendritic-cell-lineage

  7. Izawa N, Kurotaki D# (#co-first author), Nomura S, Fujita T, Omata Y, Yasui T, Hirose J, Matsumoto T, Saito T, Kadono Y, Okada H, Miyamoto T, Tamura T, Aburatani H, Tanaka S: Cooperation of PU.1 with IRF8 and NFATc1 defines chromatin landscapes during RANKL-induced osteoclastogenesis. J Bone Miner Res 34(6): 1143-1154, 2019. 
    https://academic.oup.com/jbmr/article-abstract/34/6/1143/7605782?redirectedFrom=fulltext

  8. Kurotaki D, Nakabayashi J, Nishiyama A, Sasaki H, Kawase W, Kaneko N, Ochiai K, Igarashi K, Ozato K, Suzuki Y, Tamura T: Transcription factor IRF8 governs enhancer landscape dynamics in mononuclear phagocyte progenitors. Cell Rep 22(10): 2628-2641, 2018. 
    https://www.sciencedirect.com/science/article/pii/S2211124718302298

  9. Kurotaki D, Sasaki H, Tamura T: Transcriptional control of monocyte and macrophage development. Int Immunol 29: 97-107, 2017. Review 
    https://academic.oup.com/intimm/article/29/3/97/3098307

  10. Kurotaki D* (*corresponding author), Tamura T: Transcriptional and epigenetic regulation of innate immune cell development by the transcription factor, interferon regulatory factor-8. J Interferon Cytokine Res 36(7):433-441, 2016. Review 
    https://www.liebertpub.com/doi/10.1089/jir.2015.0138?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed

  11. Kurotaki D* (*corresponding author), Uede T, Tamura T: Functions and development of red pulp macrophages. Microbiol Immunol 59(2):55-62, 2015. Review 
    https://onlinelibrary.wiley.com/doi/10.1111/1348-0421.12228

  12. Sasaki H, Kurotaki D# (#co-first author), Osato N, Sato H, Sasaki I, Koizumi S, Wang H, Kaneda C, Nishiyama A, Kaisho T, Aburatani H, Morse HC 3rd, Ozato K, Tamura T: Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells. Blood 125(2):358-369, 2015. 
    https://ashpublications.org/blood/article/125/2/358/34275/Transcription-factor-IRF8-plays-a-critical-role-in

  13. Kurotaki D, Yamamoto M, Nishiyama A, Uno K, Ban T, Ichino M, Sasaki H, Matsunaga S, Yoshinari M, Ryo A, Nakazawa M, Ozato K, Tamura T: IRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils. Nat Commun 5:4978, 2014. 
    https://www.nature.com/articles/ncomms5978

  14. Kurotaki D, Osato N, Nishiyama A, Yamamoto M, Ban T, Sato H, Nakabayashi J, Umehara M, Miyake N, Matsumoto N, Nakazawa M, Ozato K, Tamura T: Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation. Blood 121(10):1839-1849, 2013. 
    https://ashpublications.org/blood/article/121/10/1839/31201/Essential-role-of-the-IRF8-KLF4-transcription

  15. Kurotaki D, Kon S, Bae K, Ito K, Matsui Y, Nakayama Y, Kanayama M, Kimura C, Narita Y, Nishimura T, Iwabuchi K, Mack M, van Rooijen N, Sakaguchi S, Uede T, Morimoto J: CSF-1-dependent red pulp macrophages regulate CD4 T cell responses. J Immunol 186(4):2229-2237, 2011. 
    https://academic.oup.com/jimmunol/article/186/4/2229/7990231

  16. Kanayama M, Kurotaki D# (#co-first author), Morimoto J, Asano T, Matsui Y, Nakayama Y, Saito Y, Ito K, Kimura C, Iwasaki N, Suzuki K, Harada T, Li HM, Uehara J, Miyazaki T, Minami A, Kon S, Uede T. Alpha9 integrin and its ligands constitute critical joint microenvironments for development of autoimmune arthritis. J Immunol 182(12):8015-25, 2009. 
    https://academic.oup.com/jimmunol/article/182/12/8015/8007212?login=true